Liver disease may, in some cases, be related to upper right back pain, particularly below or near the right shoulder blade. The liver is located in the upper right part of the abdomen, and pain that radiates to the back could be due to inflammation or enlargement caused by hepatitis, liver abscesses, fatty liver disease, or liver tumors. These are accompanied by fatigue, jaundice (yellowing of the eyes and skin), nausea, and enlargement of the upper abdomen, which are often described as dull or throbbing.