Tag: NCBI

Improving the tolerability of antiseizure medications: When and how to use cenobamate and other new antiseizure medications

Despite the introduction of newer antiseizure medications (ASMs) with improved safety profiles over the past several years, rates of treatment-related intolerable adverse events (AEs) for people with epilepsy have not changed substantially. Tolerability issues can potentially jeopardize optimal dosing and effectiveness, regimen adherence, and treatment retention with these newer medications. Long-term clinical studies, open-label extension […]

“How-to”: scoping review? – PubMed

Background and objective: Scoping reviews are a type of evidence synthesis that aims to identify and map the breadth of evidence available on a particular topic, field, concept, or issue, within or across a defined context or contexts. Scoping reviews can contribute to clinical practice guideline development, policy making, reduce research waste by eliminating duplication […]

How to Design an Inhaled Drug: CHF-6523

Inhalation provides an opportunity to target drugs to the lung, potentially improving efficacy and safety margins for the treatment of respiratory conditions. The discovery of inhaled medicines is a specialized endeavor and has different challenges to medicinal chemistry for oral drugs. The appearance of a successful campaign delivering an inhaled PI3Kδ inhibitor is therefore an […]

How to talk to parents

Review doi: 10.1007/s00247-024-06146-6. Online ahead of print. Affiliations Expand Affiliations 1 Paediatric and prenatal radiology department, Hôpital Timone Enfants, APHM, 264 rue Saint Pierre, Marseille, 13005, France. antoine.martin-champetier@ap-hm.fr. 2 Paediatric and prenatal radiology department, Hôpital Timone Enfants, APHM, 264 rue Saint Pierre, Marseille, 13005, France. Item in Clipboard Review Antoine Martin-Champetier et al. Pediatr Radiol. 2025. […]