Improving the tolerability of antiseizure medications: When and how to use cenobamate and other new antiseizure medications

Despite the introduction of newer antiseizure medications (ASMs) with improved safety profiles over the past several years, rates of treatment-related intolerable adverse events (AEs) for people with epilepsy have not changed substantially. Tolerability issues can potentially jeopardize optimal dosing and effectiveness, regimen adherence, and treatment retention with these newer medications. Long-term clinical studies, open-label extension […]

“How-to”: scoping review? – PubMed

Background and objective: Scoping reviews are a type of evidence synthesis that aims to identify and map the breadth of evidence available on a particular topic, field, concept, or issue, within or across a defined context or contexts. Scoping reviews can contribute to clinical practice guideline development, policy making, reduce research waste by eliminating duplication […]

How to talk to parents

Review doi: 10.1007/s00247-024-06146-6. Online ahead of print. Affiliations Expand Affiliations 1 Paediatric and prenatal radiology department, Hôpital Timone Enfants, APHM, 264 rue Saint Pierre, Marseille, 13005, France. antoine.martin-champetier@ap-hm.fr. 2 Paediatric and prenatal radiology department, Hôpital Timone Enfants, APHM, 264 rue Saint Pierre, Marseille, 13005, France. Item in Clipboard Review Antoine Martin-Champetier et al. Pediatr Radiol. 2025. […]

Femoral Large Bore Sheath Management: How to Prevent Vascular Complications From Vessel Puncture to Sheath Removal

Transfemoral access is nowadays required for an increasing number of percutaneous procedures, such as structural heart interventions, mechanical circulatory support, and interventional electrophysiology/pacing. Despite technological advancements and improved techniques, these devices necessitate large-bore (≥12 French) arterial/venous sheaths, posing a significant risk of bleeding and vascular complications, whose occurrence has been related to an increase in […]